Redskins linebacker Zach Brown -- the NFL leader in tackles this season -- will be out for Sunday's game against the Cardinals as he deals with multiple injuries.

This week's injury report is brought to you by Inova, the Official Health System of the Washington Redskins.

Returning home for the first time in almost a month, the Washington Redskins head into Sunday's game against the Arizona Cardinals with linebacker Zach Brown (illness/Achilles/toe/hip) and safety Montae Nicholson (concussion) ruled out. 

Linebacker Ryan Anderson (ankle), tackles Morgan Moses (ankle) and Trent Williams (knee), wide receivers Ryan Grant (ankle) and Maurice Harris (concussion), center Chase Roullier (hand) and defensive lineman Terrell McClain (toe) questionable for the contest.

Brown has battled through numerous lower body injuries this season, but the University of North Carolina product did not practice this week due to an illness as well.

Signed by the Redskins during the offseason, Brown has not only been one of Washington's most productive defensive players (he leads the NFL in tackles) but a mainstay in the middle of a lineup that has experienced constant change due to injuries.

While Brown has started all 13 regular season games so far this year for the Redskins, Will Compton, Mason Foster, Zach Vigil and Martrell Spaight have all started alongside the 2016 Pro Bowler and rookie Josh Harvey-Clemons has also received snaps in recent weeks, too.

Brown's presence also kept the line of communication open throughout the defense, although Redskins defensive coordinator Greg Manusky said that facet of the game must improve regardless of who is in the lineup on Sunday.

"They have got to be all on the same page and I think at times [last week] we weren't on the same page," Manusky said. "Like I said early on in training camp, it doesn't matter what call that I call as long as we are all on the same page. So it has got to be from the back to the front and then to the front to the back."

Now the Redskins will look to Zach Vigil, Martrell Spaight, Josh Harvey-Clemons and Otha Peters to produce at the inside linebacker spot. 

"Well, I think with any player that gets hurt or injured, we have backup players and that's what they are supposed to be there for," Manusky said. "I was as a player more of a backup player, and guys went down and you have got to show up and you have got to go in there and you have got to fulfill the requirements that everybody wants you to fill. From my standpoint, those backup players are going to be in a position to get the calls, get them right and then go out there and play their butts off."

Although this is the first game Brown has missed this season, the Redskins will be without Nicholson once again as the rookie remains in the concussion protocol.

If Nicholson can return to full health before season's end, the coaching staff's hope is that he can get more game reps. The Michigan State product started the year as one of the team's reserve safeties before earning a spot in the starting lineup.

In eight games so far this year, the 22-year-old has recorded 24 tackles with two passes defensed and an interception.

"He's obviously showed a lot of promise and we love him as a player and an athlete and the more we can get him to play this year, the better," said Redskins head coach Jay Gruden this week. "We'll be patient with him, obviously his health is No. 1, and we want to make sure he's 100 percent. We have to make sure he's 100 percent, and he has to feel right for him to be comfortable out there."

Offensively, Moses and Williams are once again listed as questionable although both played last week against the Los Angeles Chargers.

If active, the pair will look to slow a Cardinals pass rush headlined by Chandler Jones, the NFL's leader in sacks with 14.

Roullier, meanwhile, could return from a three-game absence after suffering a fractured hand in Week 11. Vetern Tony Bergstrom has taken over center duties while Roullier has been sidelined.